EFFECTIVENESS OF RED DRAGON FRUIT MEAT AND SKIN (HYLOCEREUS POLYRHIZUS) AGAINST BACTERIAL GROWTH STAPHYLOCOCCUS AUREUS (DIABETIC ULCER) IN VITRO

Abstract

Abstract: Diabetic foot is a major consequence of neuropathy and peripheral vascular disease. Foot ulcers in diabetics increase the risk of amputation or even death. One plant that is thought to have an antibacterial effect and is starting to be consumed by many Indonesians is dragon fruit. This study aims to determine the effect of red dragon fruit on the bacteria that cause diabetic ulcers. The hypothesis in this study is that there are differences in the inhibition of bacterial growth Staphylococcus aureus after administration of red dragon fruit with a concentration of 25%, 50%, 75% and 95%. This research was conducted using a one-factor Completely Randomized Design (CRD), namely red dragon fruit flesh and red dragon fruit skin with concentrations of 15%, 25%, 50%, 75% and 95% respectively. The positive control is amoxicillin, and the negative control is sterile aquadest. The research began on August 12 2019 to November 14 2019 at the Health Analyst Laboratory of the East Kalimantan Ministry of Health Polytechnic. The results of research on the concentration of inhibition on bacteria Staphylococcus aureus the highest inhibition zone was in red dragon fruit skin decoction with a concentration of 95%, namely 7 mm (medium inhibition). Decoction of red dragon fruit skin with a concentration of 95% has the highest inhibition zone against bacterial growthStaphylococcus aureus compared to boiled dragon fruit flesh.

Keywords: red dragon fruit flesh and skin,Staphylococcus aureus